(Definition of buccal from the Cambridge Advanced Learner's Dictionary & Thesaurus © Cambridge University Press) Buccal administration is a topical route of administration by which drugs held or applied in the buccal (/ ˈbʌkəl /) area (in the cheek) diffuse through the oral mucosa (tissues which line the mouth) and enter directly into the bloodstream. The buccal region encompasses the inner surface of the cheek, which is lined by a specialized tissue called the buccal mucosa. This mucosa is a smooth, moist membrane that forms the interior boundary of the oral cavity. Adjective buccal (not comparable) (anatomy, dentistry, relational) Of, relating to, near, involving, or supplying the cheek. “Buccal” and “buckle” may sound alike, but only buccal is a true dental term referring to the cheek-facing surface of the teeth. Knowing the difference—and understanding how the buccal surface is examined, cleaned, and treated—can make your dental visits smoother and help you take a more active role in caring for your smile. buccal relating to the mouth cavity. For example, buccal epithelium lines the inside of the cheeks. The meaning of BUCCAL is of, relating to, near, involving, or supplying a cheek. How to use buccal in a sentence. Buccal in dental terms refers to the outer surfaces of your teeth that are closest to your cheeks or lips. These surfaces play a crucial role in chewing and overall oral health. BUCCAL definition: of or relating to the cheek. See examples of buccal used in a sentence. One such term that frequently arises in dental evaluations, documentation, and procedures is “buccal.” The buccal surface refers to the outer surface of a tooth that faces the cheeks, particularly in the posterior teeth such as molars and premolars.